About ZAVEDOS 1MG/ML Solution for Injection

ZAVEDOS 1MG/ML Solution for Injection contains Carboplatin, an advanced antineoplastic agent used in various chemotherapy regimens. Manufactured by Fresenius Kabi, this medication is crucial for patients undergoing cancer treatment.

As a platinum-based compound, Carboplatin works by forming DNA cross-links, which inhibits DNA synthesis and function in cancer cells, ultimately leading to their death. It is an essential component in the management of different types of cancer, including ovarian, lung, and head and neck cancers.

Benefits of ZAVEDOS

• Effective antineoplastic action against a wide range of solid tumors.
• Plays a vital role in combination chemotherapy protocols.
• A key treatment option for advanced ovarian carcinoma, small cell lung cancer, and squamous cell carcinoma of the head and neck.
• Contributes to controlling tumor growth and extending patient survival.

How to Use ZAVEDOS

1. ZAVEDOS 1MG/ML Solution for Injection is for intravenous administration only.
2. It must be administered by a qualified healthcare professional experienced in oncology.
3. The dosage and administration schedule are highly individualized and determined by the treating physician based on the patient's specific cancer type, stage, body surface area, and renal function.
4. The solution is typically diluted before infusion and given over a prescribed period.
5. Regular monitoring of blood counts, kidney function, and neurological status is essential throughout treatment.

Caution & Warnings

• Myelosuppression: ZAVEDOS can cause severe bone marrow suppression, leading to low blood cell counts (anemia, leukopenia, thrombocytopenia). Close monitoring of complete blood counts is mandatory.
• Hypersensitivity Reactions: Allergic reactions, including anaphylaxis, can occur, particularly after multiple doses. Facilities for managing anaphylaxis should be available.
• Renal Toxicity: Carboplatin can cause kidney damage. Renal function should be assessed before and during treatment.
• Neurotoxicity: Peripheral neuropathy, characterized by tingling, numbness, or weakness, may develop, especially with prolonged treatment.
• Nausea and Vomiting: These are common side effects and may require prophylactic antiemetic treatment.
• Pregnancy and Lactation: ZAVEDOS is contraindicated during pregnancy due to potential fetal harm. Women of childbearing potential should use effective contraception during and for a period after treatment. Breastfeeding is not recommended.
• Drug Interactions: Inform your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements, as interactions can occur.
• Storage: Store the vial at controlled room temperature, away from light. Do not freeze.

Ingredients

Each milliliter of ZAVEDOS 1MG/ML Solution for Injection contains:

• Active Ingredient: Carboplatin 1 mg
• Excipients: Water for Injection, Sodium Chloride (quantity sufficient for isotonicity).

Product Details

• Brand: Zavedos
• Manufacturer: Fresenius Kabi
• Dosage Form: Solution for Injection
• Strength: 1 mg/ml
• Packaging: 10 ml Vial
• Therapeutic Class: Antineoplastic Agent