Product Details: XIGDUO XR 10 mg/500 mg Film Coated Tablet

XIGDUO XR 10 mg/500 mg Film Coated Tablet is a prescription medication designed for adults with type 2 diabetes mellitus. It combines two active ingredients, dapagliflozin and metformin hydrochloride, working synergistically to improve blood sugar control. Dapagliflozin, an SGLT2 inhibitor, helps the kidneys remove glucose from the body, while metformin, a biguanide, reduces glucose production by the liver and improves insulin sensitivity. This extended-release formulation provides convenient once-daily dosing.

About XIGDUO XR

XIGDUO XR is an innovative combination therapy from AstraZeneca for managing type 2 diabetes. It is specifically formulated to help patients achieve better glycemic control, often with the added benefits of weight reduction and a reduced risk of hospitalization for heart failure or cardiovascular death in patients with established cardiovascular disease or multiple cardiovascular risk factors.

Benefits of Use:

• Helps lower and control blood sugar levels effectively in adults with type 2 diabetes.
• May contribute to weight loss in some patients.
• Can reduce the risk of hospitalization for heart failure and cardiovascular death in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors.
• Convenient once-daily dosing with its extended-release formulation.

How to Use:

1. Take XIGDUO XR exactly as prescribed by your doctor.
2. It is usually taken once daily in the morning, with food.
3. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
4. Do not stop taking XIGDUO XR without consulting your doctor.

Caution & Warnings:

• Hypoglycemia (Low Blood Sugar): Risk increases if taken with insulin or sulfonylureas. Monitor blood sugar regularly.
• Lactic Acidosis: A rare but serious side effect of metformin. Seek immediate medical attention if symptoms like unusual muscle pain, trouble breathing, or abdominal pain occur.
• Dehydration: Dapagliflozin can cause fluid loss, leading to dehydration and low blood pressure. Drink adequate fluids.
• Kidney Problems: Not recommended for patients with severe kidney impairment. Kidney function should be monitored.
• Genital Yeast Infections and Urinary Tract Infections: More common with dapagliflozin.
• Diabetic Ketoacidosis (DKA): A serious condition that can occur with SGLT2 inhibitors, even with normal or slightly elevated blood sugar levels.
• Vitamin B12 Deficiency: Metformin may lead to reduced vitamin B12 levels over time.
• Not for Type 1 Diabetes: XIGDUO XR is not for the treatment of type 1 diabetes or diabetic ketoacidosis.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Ingredients:

• Active Ingredients: Dapagliflozin (10 mg) and Metformin Hydrochloride (500 mg).
• Inactive Ingredients: Typically include microcrystalline cellulose, hypromellose, magnesium stearate, carboxymethylcellulose sodium, titanium dioxide, macrogol, and iron oxides for the film coating.

Product Details:

• Dosage Form: Film-Coated Extended-Release Tablets
• Manufacturer: AstraZeneca
• Legal Status: Prescription Only Medicine (POM)
• Storage Conditions: Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.