HOLOXAN 500MG VIAL IV 500 Powder for injection Vial

Product Overview

HOLOXAN 500MG VIAL is a potent chemotherapy agent for intravenous administration.

It is prescribed for various types of cancer, working to interfere with cancer cell growth.

This product is typically sourced through specialized pharmaceutical distributors and healthcare providers, similar to those found on platforms like Nahdi Online, , and , ensuring professional handling and medical oversight.

Benefits of Use

• HOLOXAN (Ifosfamide) is an essential medication in the treatment protocols for several types of cancer.
• It is effective against a broad spectrum of malignancies, including germ cell testicular cancer, soft tissue sarcoma, osteosarcoma, breast cancer, lung cancer, and lymphomas.
• As an alkylating agent, Ifosfamide works by cross-linking DNA strands, inhibiting DNA synthesis and function, which ultimately leads to the death of rapidly dividing cancer cells.
• Its mechanism of action makes it a valuable component in multi-drug chemotherapy regimens.

How to Use

1. HOLOXAN 500MG VIAL is a sterile powder that must be reconstituted with a suitable diluent (e.g., Sterile Water for Injection) before intravenous administration.
2. Reconstitution and further dilution should only be performed by trained healthcare professionals in an aseptic environment.
3. The specific dosage, duration of treatment, and infusion rate will be determined by your physician based on the type and stage of cancer, your body surface area, and your overall health.
4. It is typically administered as a slow intravenous infusion over several hours, often accompanied by Mesna to prevent hemorrhagic cystitis.
5. Strict adherence to the prescribed regimen and close monitoring by a medical team are crucial throughout the treatment course.

Caution & Warnings

• HOLOXAN should only be administered under the direct supervision of a physician experienced in antineoplastic chemotherapy.
• Hemorrhagic Cystitis: A severe and potentially life-threatening bladder inflammation can occur. Mesna must be co-administered as a uroprotectant.
• Myelosuppression: Bone marrow suppression, leading to severe reduction in white blood cells (leukopenia), red blood cells (anemia), and platelets (thrombocytopenia), is a common and dose-limiting toxicity. Frequent monitoring of blood counts is essential.
• Neurotoxicity: Encephalopathy (brain dysfunction) can occur, manifesting as confusion, lethargy, hallucinations, and seizures. Patients should be monitored for neurological symptoms.
• Nephrotoxicity: Kidney damage, including renal tubular dysfunction and renal failure, is a known risk. Regular monitoring of renal function is required.
• Cardiotoxicity: Cardiac dysfunction, including congestive heart failure, has been reported.
• Pulmonary Toxicity: Interstitial pneumonitis and fibrosis can occur.
• Gastrointestinal Effects: Nausea, vomiting, and mucositis are common side effects.
• Fertility Impairment: Ifosfamide can cause permanent infertility in both males and females.
• Teratogenicity: It is teratogenic and embryotoxic; effective contraception is required during and for a period after treatment for both male and female patients.
• Hypersensitivity Reactions: Allergic reactions can occur; immediate medical attention is required for any signs of anaphylaxis.

Ingredients

Each vial contains 500 mg of Ifosfamide as the active pharmaceutical ingredient.

Excipients may include mannitol (for lyophilization) and/or pH adjusters (e.g., sodium hydroxide or hydrochloric acid), depending on the specific formulation. Refer to the official package insert for a complete list.

Product Details

Form: Sterile Powder for Injection

Strength: 500 mg per vial

Route of Administration: Intravenous

Storage: Store below 25°C. Protect from light. Keep out of reach of children.

Manufacturer: Baxter