Gemcitabine 1000 mg/vial – A Potent Antineoplastic Agent

Benefits of Use:

• Effective in slowing or stopping the growth of various solid tumors.
• Contributes to improved patient outcomes and survival rates in several cancer types.
• Administered as part of combination therapy or as a single agent, providing flexibility in treatment regimens.
• Helps in managing symptoms related to cancer progression in some cases.

How to Use:

1. Gemcitabine is for intravenous administration only.
2. It must be prepared and administered by a qualified healthcare professional experienced in the use of antineoplastic agents.
3. The dosage and administration schedule are determined by the physician based on the patient's type of cancer, body surface area, and response to treatment.
4. Typically, Gemcitabine is given as an intravenous infusion over 30 minutes.
5. It may be administered weekly or on other schedules as prescribed by the oncologist.

Caution & Warnings:

• Severe Myelosuppression: May cause suppression of bone marrow function, leading to reduced white blood cells, red blood cells, and platelets. Regular blood counts are essential.
• Pulmonary Toxicity: Serious lung problems, including interstitial pneumonitis and pulmonary fibrosis, can occur. Patients should be monitored for respiratory symptoms.
• Hepatotoxicity: Liver enzyme elevations are common. Liver function tests should be performed periodically.
• Renal Dysfunction: Kidney problems, including hemolytic uremic syndrome, have been reported.
• Radiation Recall: May exacerbate radiation-induced skin or mucosal reactions.
• Pregnancy and Breastfeeding: Gemcitabine can cause fetal harm. It is contraindicated in pregnant or breastfeeding women. Effective contraception should be used by both male and female patients during and after treatment.
• Extravasation Risk: Care should be taken during administration to avoid extravasation, which can cause tissue damage.
• Drug Interactions: Inform your doctor about all medications, supplements, and herbal products you are using, as interactions may occur.

Ingredients:

• Active Ingredient: Gemcitabine Hydrochloride 1000 mg
• Inactive Ingredients: (Typically includes mannitol, sodium acetate, hydrochloric acid for pH adjustment, and/or sodium hydroxide for pH adjustment in powder for solution formulations; for liquid formulations, sterile water for injection and other excipients). Specific inactive ingredients may vary by manufacturer.

Product Details:

• Strength: 1000 mg Gemcitabine (as hydrochloride) per vial
• Form: Solution for Infusion (or Powder for Solution for Infusion, depending on specific product variant)
• Packaging: Single-dose vial containing 1000 mg of Gemcitabine. The vial is designed to deliver a total of 1000 mg, possibly as a 10 mg/mL concentration in a 100 mL volume.
• Manufacturer: Not provided.
• Storage: Store intact vials at controlled room temperature, typically 20°C to 25°C (68°F to 77°F). Protect from light. Reconstituted solutions have specific storage requirements and shelf-life, usually requiring refrigeration and use within 24 hours.