Endoxan 50 mg Film-Coated Tablets - Comprehensive Information

Endoxan 50 mg Film-Coated Tablets contain cyclophosphamide, an active ingredient belonging to a class of medicines called alkylating agents. These tablets are used in the treatment of various types of cancer and certain autoimmune diseases. It is a potent medication that works by interfering with the growth of cancer cells, which are eventually destroyed by the body.

Product Details

Endoxan 50 mg Film-Coated Tablets are manufactured by Baxter Oncology GmbH, a leading pharmaceutical company. Each tablet is formulated to deliver a precise dose of 50 mg of cyclophosphamide. The film-coating helps in easier swallowing and protects the active ingredient. This medication is essential in protocols for various malignancies and severe autoimmune conditions.

Benefits of Use

• Treatment of various types of lymphomas (e.g., non-Hodgkin's lymphoma, Hodgkin's lymphoma).
• Management of different forms of leukemias (e.g., acute myeloid leukemia, chronic lymphocytic leukemia).
• Adjuvant and palliative treatment of solid tumors such as breast cancer, ovarian cancer, and small cell lung cancer.
• Therapy for multiple myeloma.
• Treatment of severe progressive forms of autoimmune diseases like severe rheumatoid arthritis, systemic lupus erythematosus, and vasculitis, when other treatments have failed.
• Conditioning regimens before bone marrow transplantation.

How to Use

1. Always follow your doctor's instructions precisely when taking Endoxan 50 mg Film-Coated Tablets.
2. Dosage and duration of treatment are highly individualized.
3. Swallow the tablets whole with a glass of water. Do not chew or crush them.
4. It is generally recommended to take Endoxan in the morning to allow for adequate fluid intake and frequent urination during the day, which helps prevent bladder complications.
5. Ensure you drink plenty of fluids throughout the day as advised by your healthcare provider to help protect your kidneys and bladder.
6. Do not stop taking Endoxan or change your dose without consulting your doctor.
7. If you miss a dose, contact your doctor immediately for advice. Do not take a double dose to make up for a missed one.

Caution & Warnings

• Endoxan must only be used under the strict supervision of a physician experienced in chemotherapy.
• Regular blood tests, including complete blood count and kidney/liver function tests, will be required during treatment.
• Urinalysis will be performed regularly to monitor for bladder irritation or damage.
• Inform your doctor about all other medications you are taking, including herbal remedies and supplements, as interactions can occur.
• Avoid alcohol consumption during treatment as it may increase side effects.
• This medicine can cause severe side effects, including bone marrow suppression (leading to infections, anemia, bleeding), bladder inflammation (hemorrhagic cystitis), cardiotoxicity, and pulmonary fibrosis.
• Endoxan may cause temporary or permanent infertility in both men and women. Discuss fertility preservation options with your doctor before starting treatment.
• It is highly contraindicated during pregnancy and breastfeeding. Effective contraception must be used by both men and women during and for a certain period after treatment.
• Store Endoxan below 25°C, away from light and moisture, in its original packaging.
• Keep out of reach and sight of children.

Ingredients

• Active Ingredient: Cyclophosphamide 50 mg
• Excipients: Lactose monohydrate, calcium hydrogen phosphate dihydrate, maize starch, gelatin, talc, magnesium stearate.
• Film Coating: Sucrose, talc, calcium carbonate, macrogol 35000, titanium dioxide (E171), silica colloidal anhydrous, povidone K25, carmellose sodium, polysorbate 80, carnauba wax.