Cisplatin 1 mg/ml VIAL 1 Solution for infusion 50ml Vial

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Product Details

Cisplatin 1 mg/ml Solution for Infusion is a potent antineoplastic agent manufactured by Accord Healthcare, designed for the intravenous treatment of various cancers. Each 50ml vial contains 50mg of Cisplatin, formulated as a clear, colorless solution, ready for dilution and infusion. This medication is a cornerstone in chemotherapy regimens, renowned for its efficacy in a broad spectrum of malignancies. As a platinum-based compound, Cisplatin interferes with DNA replication, leading to cell death in rapidly dividing cancer cells.

Benefits of Use

• Effective in treating a wide range of solid tumors, including testicular, ovarian, bladder, head and neck, esophageal, small cell lung, and non-small cell lung cancers.
• Often used in combination therapy to enhance therapeutic outcomes and broaden the spectrum of anticancer activity.
• A well-established and clinically proven chemotherapy drug with decades of use in oncology.
• Administered under strict medical supervision, ensuring precise dosing and patient monitoring.

How to Use

1. Cisplatin 1 mg/ml Solution for Infusion must be administered strictly by qualified healthcare professionals experienced in oncology.
2. The medication is for intravenous infusion only, typically after dilution in appropriate infusion fluids (e.g., 0.9% Sodium Chloride injection).
3. Dosage and administration schedule are highly individualized, determined by the patient's specific cancer type, stage, body surface area, renal function, and overall health status.
4. Prior to administration, patients usually receive adequate hydration and may be given antiemetic prophylaxis to manage potential side effects like nausea and vomiting.
5. Close monitoring of renal function, electrolytes, audiology, and neurological status is essential throughout the treatment course.

Caution & Warnings

• Severe Side Effects: Cisplatin can cause significant and potentially irreversible side effects, including severe renal toxicity (kidney damage), ototoxicity (hearing loss, especially high frequency), neurotoxicity (peripheral neuropathy), and myelosuppression (bone marrow suppression leading to reduced blood cell counts).
• Hypersensitivity Reactions: Acute anaphylactic-like reactions have been reported, requiring immediate medical intervention. Patients should be monitored closely during and after administration.
• Contraindications: Contraindicated in patients with pre-existing renal impairment, hearing impairment, myelosuppression, or a history of allergic reactions to platinum-containing compounds.
• Pregnancy and Lactation: Cisplatin is classified as Pregnancy Category D. It can cause fetal harm and should not be used during pregnancy. Breastfeeding is not recommended during treatment.
• Electrolyte Disturbances: Can lead to severe electrolyte imbalances, particularly hypomagnesemia, hypokalemia, hypocalcemia, and hypophosphatemia, requiring careful monitoring and supplementation.
• Extravasation: Avoid extravasation as it can cause severe tissue damage. Administer through a patent intravenous line.

Ingredients

• Active Ingredient: Cisplatin (1 mg/ml, equivalent to 50 mg per 50 ml vial)
• Excipients: Sodium chloride, hydrochloric acid (for pH adjustment), water for injections.