Calcium Folinate Hainan 350 mg vial

Product Overview

Calcium Folinate Hainan 350 mg vial is a vital pharmaceutical product, primarily used in clinical settings to mitigate the harmful effects of certain medications and to address specific nutritional deficiencies. As referenced on leading pharmacy platforms like , , and , this medication contains Calcium Folinate, a reduced form of folic acid, which is biologically active and does not require enzymatic reduction to be utilized by the body.

This product is often prescribed as a 'Leucovorin rescue' following high-dose methotrexate therapy, commonly used in cancer treatment. It helps protect healthy cells from the cytotoxic effects of methotrexate, allowing for effective treatment while minimizing severe side effects. Additionally, Calcium Folinate is indicated for the treatment of megaloblastic anemia due to folate deficiency, a condition where the bone marrow produces abnormally large, immature red blood cells.

Benefits of Use

• Mitigates severe side effects of folic acid antagonists like methotrexate, protecting healthy cells.
• Supports the treatment of megaloblastic anemia caused by folate deficiency.
• Enhances the cytotoxic effect of fluorouracil in the treatment of advanced colorectal cancer.
• Provides an immediate source of reduced folate for various metabolic processes.

How to Use

1. Calcium Folinate Hainan 350 mg vial is for parenteral administration only (intravenous or intramuscular injection).
2. The dosage and administration schedule are highly individualized and depend on the specific medical condition being treated, the patient's response, and other concurrent therapies.
3. It must be administered under the direct supervision of a healthcare professional experienced in oncology or hematology.
4. For 'Leucovorin rescue', administration typically begins 12-24 hours after the start of methotrexate infusion.
5. The vial contents may need to be reconstituted or diluted before administration, following the manufacturer's instructions and aseptic techniques.

Caution & Warnings

• Calcium Folinate should only be administered by qualified healthcare professionals.
• Not to be used in pernicious anemia or other megaloblastic anemias secondary to Vitamin B12 deficiency, as it may mask the neurological symptoms while hematological abnormalities improve.
• Strict adherence to dosing schedules and monitoring protocols is crucial, especially when used as a rescue therapy for methotrexate.
• Monitor for hypersensitivity reactions; discontinue immediately if symptoms of anaphylaxis occur.
• Use with caution in patients with a history of seizures or renal impairment.
• Keep out of reach of children.

Ingredients

Each vial contains 350 mg of Calcium Folinate as the active ingredient. Excipients may include sodium chloride and water for injection.

Product Details

• Manufacturer: Hainan Pharmaceutical Factory Co., Ltd.
• Form: Solution for injection in a vial.
• Strength: 350 mg per vial.
• Storage: Store at controlled room temperature, typically below 25°C (77°F), and protect from light. Do not freeze.
• Legal Status: Prescription Only Medicine (POM).