CALCIUM FOLINATE 50MG-5ML VIAL 10 mg/ml Solution

Calcium Folinate 50mg/5ml Solution for Injection, manufactured by Hikma Pharmaceuticals, is a vital medication.

It is primarily used in cancer treatment and to manage specific nutritional deficiencies.

This sterile solution contains 10 mg/ml of Calcium Folinate, with each 5ml vial delivering a total of 50mg of the active ingredient.

It is designed for parenteral administration under strict medical supervision.

Product Details

Form: Solution for Injection

Strength: 10 mg/ml (50 mg per 5ml vial)

Package Type: Vial

Manufacturer: Hikma Pharmaceuticals

Drug Type: Prescription only medicine (POM)

Benefits of Use

This medication offers several crucial therapeutic benefits:

• Methotrexate Antidote: It is effectively used as a "leucovorin rescue" to counteract the severe toxic effects of methotrexate, a potent chemotherapy agent, on healthy cells, particularly bone marrow and gastrointestinal mucosa.
• Fluorouracil Enhancement: When used in combination with fluorouracil, Calcium Folinate significantly enhances the anticancer activity of fluorouracil in the treatment of colorectal cancer.
• Megaloblastic Anemia Treatment: It can be administered for the treatment of megaloblastic anemia due to folate deficiency when oral therapy is inappropriate or ineffective.

How to Use

Calcium Folinate Solution for Injection must be administered by a qualified healthcare professional.

The dosage and duration of treatment vary significantly based on the patient's condition, the specific therapeutic regimen (e.g., methotrexate rescue, fluorouracil potentiation), and individual response.

Key administration points include:

1. Administration Route: Typically administered intravenously (IV) or intramuscularly (IM). The intravenous route is preferred for higher doses.
2. Preparation: The solution is sterile and ready for use. It may be diluted in normal saline or 5% dextrose solution for intravenous infusion, following specific guidelines.
3. Dosage: Follow the prescribing physician's instructions precisely. Do not self-administer or alter the prescribed dose.
4. Monitoring: Patients will require regular monitoring of blood counts and other laboratory parameters throughout treatment to ensure safety and efficacy.

Caution & Warnings

• Not for Pernicious Anemia: Calcium Folinate is not indicated for the treatment of pernicious anemia or other megaloblastic anemias caused by vitamin B12 deficiency. It may mask the hematological symptoms while neurological damage progresses.
• Interactions: Exercise caution when co-administering with certain medications such as phenobarbital, phenytoin, and primidone, as Calcium Folinate may reduce their efficacy.
• Hypersensitivity: Hypersensitivity reactions, including anaphylaxis, can occur. Facilities for managing anaphylactic shock should be readily available.
• Pregnancy & Lactation: Use during pregnancy and lactation only if clearly necessary and potential benefits outweigh risks, as directed by a healthcare provider.
• Storage: Store below 25°C. Protect from light. Do not freeze. Keep out of reach and sight of children.

Ingredients

Active Ingredient: Calcium Folinate (50 mg per 5 ml vial, equivalent to 10 mg/ml)

Excipients: Water for Injection and other pharmaceutical grade excipients as per formulation.